**Selected for 2025 Doody’s Core Titles® in Rheumatology** Symptomatic: The Symptom-Based Handbook for Ehlers-Danlos Syndromes and Hypermobility Spectrum Disorders offers a novel approach to the subject, structured around the panoply of symptoms those with Ehlers-Danlos syndromes and hypermobility spectrum disorders may describe to their clinicians. The content is arranged intuitively from head to feet. Each chapter integrates a clinical case study with a concise discussion and two important tools: a simplified algorithm for diagnosing and managing each symptom; and differential diagnoses (i.e. alternative explanations) for the symptoms. Combining the expertise of some 70 leading clinicians representing more than 30 specialties, the content is suited for clinicians who need a concise presentation of the various and complex symptoms they confront in their practice. It also aims to inform and empower patients, helping them understand the nature of these concerns and their management. This handbook advances an integrative understanding of this emerging interdisciplinary field, bridging the gaps between the several dozen specialties germane to EDS and HSD.

Table of Contents:
1. Introduction PART I - SYSTEMIC SYMPTOMS Section I.I - General 2. Joint hypermobility and pain 3. Chronic Widespread Pain 4. Widespread pain in childhood 5. Myofascial Pain 6. Multiple unexplained symptoms 7. Itchy rash and general malaise Section I.II - Fatigue 8. Fatigue 9. Brain fog Section I.III - Skin 10. Stretched, unsightly scars 11. Bruising and bleeding 12. Poor wound healing 13. Repeated joint dislocation and bruising PART II - HEAD AND NECK Section II.I - Psychological health 14. Anxiety 15. Depression 16. Posttraumatic stress 17. Attention difficulties 18. Loneliness and social isolation Section II.II - Head and neck 19. Postural Headache 20. Persistent pressure headache 21. Cough-induced headache 22. Excruciating headache on the side of the head 23. Headache with shaking episodes and "brain fog" 24. Skull-base headache with intermittent burning limb pain 25. Fainting, headache, and "bobble head" 26. Pressure headache and blurry vision 27. Head, neck, and shoulder pain 28. Headache with pain and stiffness in the neck 29. Migraine Section II.III - Eyes 30. Difficulty reading 31. Blurry and double vision Section II.IV - Mouth and voice 32. Temporomandibular joint (TMJ) pain and headache 33. Gum bleeding and early tooth loss 34. Difficulty swallowing 35. Voice change PART III - TORSO Section III.I - Upper and lower back 36. Upper back pain 37. Low back pain 38. Progressive leg weakness and urinary incontinence 39. Sacral and buttock pain Section III.II - Rib cage 40. Posterior rib cage pain 41. Chest wall pain Section III.III - Lungs 42. Shortness of breath 43. Still tired after sleeping Section III.IV - Heart and cardiovascular system 44. Palpitations 45. Feeling shaky with palpitations 46. Severe abdominal pain and a cold leg Section III.V - Abdomen 47. Abdominal pain and feeding intolerance in a child 48. Chronic constipation and nausea in a child 49. Failure to thrive in a young child 50. Heartburn and feeling full, even after a small meal 51. Stomach pain and reflux failing medical management 52. Sluggish stomach 53. Persistent nausea 54. Severe constipation 55. Severe abdominal pain after eating, and weight loss 56. Stomach and midback pain with eating Section III.VI - Pelvis 57. Bladder pain with urinary frequency and urgency 58. Bulging of the bladder and vagina, with difficulty urinating 59. Rectal bulging, hemorrhoids, and difficulty emptying the bowel PART IV - LIMBS Section IV.I - Movement disorders 60. Twitching 61. Uncontrolled spasms triggered by exercise Section IV.II - Shoulder / upper limb 62. Neck pain and tingling in the arm and hand 63. Shoulder pain and/or instability 64. Painful shoulder blade 65. Intermittent pain and weakness in the arm and hand 66. Pain in the hands and reduced grip strength 67. Pain and weakness in the forearm, wrist and hand Section IV.III - Lower limb 68. Hip Pain 69. Wobbly kneecap and a painful knee 70. Swelling and redness in both feet 71. Leg swelling and pain 72. Weakness and painful numbness in the arms and legs 73. Burning pain in the feet 74. Foot pain and repeated ankle sprains 75. Painful heels, and tired and clumsy feet