About the Book
Exclusive, first of its kind, Indian, exhaustive, precise and yet concise textbook.
Highly illustrated guide to diseases and cancers of the blood in paediatrics.
It is a state-of-the-art book, compiled collectively, illustrated adequately, written elaborately, referenced scientifically, peer-reviewed carefully, printed in reader-friendly manner and priced economically.
Covers cancers of the blood and includes lymphoblastic leukaemia, myeloid leukaemia, juvenile myelomonocytic leukaemia, and bone marrow transplantation.
Each chapter is peer-reviewed, with a list of references.
Enhanced by nearly 200 images and illustrations.
It comes from editors who are reputed in the field with proven-track record with many successful and useful books in past. About the Author
Editor-in-Chief: MR Lokeshwar
Editors: Nitin K Shah, Bharat R Agarwal
Co-editors: Mamta Vijay Manglani, Anupam Sachdeva
Publication Editor: Asha Pillai
Table of Contents:
Contents
Section 1 PHYSIOLOGY
1. Ontogeny of Erythropoiesis 3
Nirav Buch
2. Physiology of Blood Coagulation 10
Shrimati Shetty
3. Structure, Function and Physiology of Platelets 15
K Ghosh, Bipin P Kulkarni
Section 2 NEONATAL HEMATOLOGY
4. Variation in the RBC Parameters in the Newborn 23
MR Lokeshwar, Ambreen Pandrowala, Jayashree Mondkar
5. Physiological Anemia of Newborn, Anemia of Prematurity and Role
of Erythropoietin in the Management 29
Rhishikesh Thakre, PS Patil
6. Effect of Maternal Iron Status on Placenta, Fetus and Newborn 36
KN Aggarwal, Vineeta Gupta, Sonika Agarwal
7. Developmental Aspects of Hemostasis in the Fetus and Newborn 41
Bhavna Dhingra, Renu Saxena
8. Anemia in the Newborn 45
Jayashree Mondkar, Shilpa Sanjay Borse, MR Lokeshwar
9. Polycythemia and Hyperviscosity Syndrome 57
MMA Faridi, Sriram Krishnamurthy
10. Vitamin K Deficiency: Bleeding in Newborns 64
Arvind Saili, Ajay Kumar
11. Bleeding Neonate: Approach and Management 68
Mamta Vijay Manglani, Neha Vilas Dighe, Ratna Sharma, MR Lokeshwar
12. Approach to Neonatal Thrombocytopenia 77
Nitin K Shah
Section 3 RBC AND WBC DISORDERS
13. Introduction and Classification of Anemias in Children 87
Manas Kalra, Satya P Yadav, Anupam Sachdeva
14. Nutritional Anemia in Infancy, Childhood and Adolescents 100
MR Lokeshwar, Nitin K Shah
xxiv Textbook of Pediatric Hematology and Hemato-Oncology
15. Megaloblastic Anemia 126
Anupa A Joshipura, Nitin K Shah
16. Anemia of Chronic Disease 149
Dilraj Kaur Kahlon, Satya P Yadav, Anupam Sachdeva
17. Thalassemia Syndromes 163
Mamta Vijay Manglani, Ambreen Pandrowala, Ratna Sharma, MR Lokeshwar
18. Sickle Cell Anemia in Children 190
Swati Kanakia, Pooja Balasubramanian, MR Lokeshwar
19. Antenatal Diagnosis of Hemoglobinopathies 204
Neerja Gupta, Sadhna Arora, Madhulika Kabra
20. Red Cell Membrane Disorders (Spherocytosis, Elliptocytosis, Stomatocytosis) 213
Sunil Gomber, Pooja Dewan
21. Red Cell Enzymopathy 219
Bhavna Dhingra, Dinesh Yadav, Jagdish Chandra
22. Autoimmune Hemolytic Anemia 227
Rajiv Kumar Bansal
23. Paroxysmal Nocturnal Hemoglobinuria 238
Farah Jijina, Sonali Sadawarte
24. Diagnosis and Management of Acquired Aplastic Anemia in Children 247
Nitin K Shah
25. Inherited Bone Marrow Failure Syndromes 255
Revathi Raj
26. Benign Disorders of Neutrophils 258
Bharat R Agarwal
Section 4 BLEEDING DISORDERS
27. Approach to a Bleeding Child 275
Raj Warrier, MR Lokeshwar, Aman Chauhan
28. Diagnosis and Management of Hemophilia Patients 285
Farah Jijina
29. von Willebrand Disease and Other Rare Coagulation Disorders 296
Kana Ram Jat, Ram Kumar Marwaha
30. Acquired Inhibitors of Coagulation 311
ATK Rau, Soundarya M
31. Immune Thrombocytopenic Purpura—Diagnosis and Management 318
MR Lokeshwar, Deepak K Changlani, Aparna Vijayaraghavan
32. Platelet Function Disorders 332
Shanaz Khodaiji
33. Pediatric Thrombosis 348
Rashmi Dalvi
34. Disseminated Intravascular Coagulation in Neonates 356
VP Choudhary
Contents xxv
Section 5 TRANSFUSION MEDICINE
35. Blood Components in Pediatric Practice 363
Nitin K Shah, Sunil Udgire
36. Nucleic Acid Amplification Testing 372
Anand Deshpande, Rajesh B Sawant
37. Transfusion Transmitted Infections 376
AP Dubey, Malobika Bhattacharya
38. Noninfectious Hazards of Blood Transfusion 384
SB Rajadhyaksha, Priti Desai
Section 6 HEMATO-ONCOLOGY
39. Pediatric Acute Lymphoblastic Leukemia 395
Pankaj Dwivedi, Shripad Banavali
40. Pediatric Acute Myeloid Leukemia 408
Maya Prasad, Shripad Banavali
41. Chronic Myeloid Leukemia 419
Nirav Thacker, Brijesh Arora
42. Juvenile Myelomonocytic Leukemia 430
Gaurav Narula, Nirmalya D Pradhan
43. Pediatric Hodgkin Lymphoma 439
Amol Dongre, Brijesh Arora
44. Non-Hodgkin Lymphoma in Children and Adolescents 451
Seema Gulia, Brijesh Arora
45. Langerhans Cell Histiocytosis 462
Gaurav Narula, Nirmalya D Pradhan
46. Hemophagocytic Lymphohistiocytosis: Revisited 470
Mukesh M Desai, Sunil Udgire
47. Bone Marrow Transplantation 479
Nita Radhakrishnan, Satya P Yadav, Anupam Sachdeva
Section 7 GENERAL
48. Gene Therapy 491
Aditya Kumar Gupta, Nita Radhakrishnan, Anupam Sachdeva
49. Monoclonal Antibodies in Pediatric Hematology and Oncology 496
Saroj P Panda, Girish Chinnaswamy
50. Biological Response Modifiers 501
Anupama S Borker, Narendra Chaudhary
Index 511
