This outstanding reference source on bone marrow transplantation has become recognised as the bible in the field. This fourth edition has been fully revised to reflect latest developments, and now features over 500 illustrations, including a colour plate section. The need for this new edition cannot be overstated - more than 13,000 new cases per year of haematopoietic stem cell transplantation have been reported to the International Bone Marrow Transplant Registry
The original editor, Donnall Thomas, was a pioneer in stem cell research and won the 1990 Nobel Prize for his discoveries concerning organ and cell transplantation in the treatment of human diseases.
The book also now includes a fully searchable CD with PDFs of the entire content.
Table of Contents:
Contributors, ix
Preface to the First Edition, xvii
Preface to the Second Edition, xviii
Preface to the Third Edition, xix
Preface to the Fourth Edition, xx
Thomas HCT Fourth Edition, xxi
List of Abbreviations, xxiii
SECTION 1: History and Use of Hematopoietic Cell Transplantation
1 A History of Allogeneic Hematopoietic Cell Transplantation, 3
E. Donnall Thomas
2 The History of Autologous Hematopoietic Cell Transplantation, 8
James O. Armitage
3 Uses and Growth of Hematopoietic Cell Transplantation, 15
Mary M. Horowitz
SECTION 2: Scientifi c Basis for Hematopoietic Cell Transplantation
Section 2a: Hematopoiesis and Stem Cell Biology
4 Generation of Defi nitive Engraftable Hematopoietic Stem Cells from Human Embryonic Stem Cells, 27
Laurence Dahéron & David T. Scadden
5 Biology of Hematopoietic Stem and Progenitor Cells, 36
Susan Prohaska & Irving Weissman
6 Molecular Biology of Stem Cell Renewal, 64
Peter M. Lansdorp
7 Cellular Biology of Hematopoiesis, 72
Catherine M. Flynn & Catherine M. Verfaillie
8 Expansion of Hematopoietic Stem Cells, 88
Colleen Delaney & Irwin Bernstein
9 Mesenchymal Stromal Cells and Hematopoietic CellTransplantation, 102
Edwin M. Horwitz
10 Genetic Manipulation of Hematopoietic Stem Cells, 116
Grant D. Trobridge & Hans-Peter Kiem
Section 2b: Immunology
11 Overview of Hematopoietic Cell Transplantation Immunology, 131
Paul J. Martin
12 Histocompatibility, 145
Eric Mickelson & Effie W. Petersdorf
13 Natural Killer Cells and Allogeneic Hematopoietic Cell Transplantation, 163
Michael R. Verneris & Jeffrey S. Miller
14 Murine Models of Graft-versus-Host Disease and Graft-versus-Tumor Effect, 176
Robert Korngold & Thea M. Friedman
15 Mechanisms of Tolerance, 188
Megan Sykes
16 The Pathophysiology of Graft-Versus-Host Disease, 208
James L.M. Ferrara & Joseph H. Antin
17 Immune Reconstitution Following Hematopoietic Cell Transplantation, 222
Robertson Parkman & Kenneth I. Weinberg
18 The Human Graft-versus-Tumor Response – and How to Exploit It, 232
Edus H. Warren
19 Dendritic Cells in Hematopoietic Cell Transplantation, 248
Miriam Merad, Matthew P. Collin & Edgar G. Engleman
20 The Experimental Basis for Hematopoietic Cell Transplantation for Autoimmune Diseases, 264
Judith A. Shizuru
Section 2c: Technical Aspects
21 Pharmacologic Basis for High-dose Chemotherapy, 289
James H. Doroshow & Timothy W. Synold
22 High-dose Preparatory Regimens, 316
William I. Bensinger
23 Radiotherapeutic Principles of Hematopoietic Cell Transplantation, 333
Jeffrey Y.C. Wong & Timothy Schultheiss
24 Radioimmunotherapy and Hematopoietic Cell Transplantation, 351
Damian J. Green & Oliver W. Press
25 Documentation of Engraftment and Characterization of Chimerism Following Hematopoietic Cell Transplantation, 365
Paul J. Martin
26 The Detection and Signifi cance of Minimal Residual Disease, 376
Jerald P. Radich & Marilyn L. Slovak
27 Pathology of Hematopoietic Cell Transplantation, 390
Howard M. Shulman, Robert C. Hackman & George E. Sale
28 Biostatistical Methods in Hematopoietic Cell Transplantation, 406
Joyce C. Niland & Paul Frankel
29 Outcomes Research in Hematopoietic Cell Transplantation, 428
Stephanie J. Lee
SECTION 3: Patient-oriented Issues in Hematopoietic Cell Transplantation
30 The Evaluation and Counseling of Candidates for Hematopoietic Cell Transplantation, 445
Karl G. Blume & Robert A. Krance
31 Nursing Role in Hematopoietic Cell Transplantation, 461
Rosemary C. Ford & Mihkaila M. Wickline
32 Ethical Issues in Hematopoietic Cell Transplantation, 478
David S. Snyder
33 Psychosocial Issues in Hematopoietic Cell Transplantation, 488
Richard P. McQuellon & Michael Andrykowski
34 Assessment of Quality of Life in Hematopoietic Cell Transplantation Recipients, 502
Karen L. Syrjala & Samantha Burns Artherholt
35 Sexuality Following Hematopoietic Cell Transplantation: An Important Health-related Quality of Life Issue, 515
D. Kathryn Tierney
36 Hematopoietic Cell Transplantation: The Patient's Perspective, 526
Susan K. Stewart
SECTION 4: Sources of Hematopoietic Cells for Hematopoietic Cell Transplantation
37 Hematopoietic Cell Procurement, Processing, and Transplantation: Standards, Accreditation, and Regulation, 535
Phyllis I. Warkentin & Elizabeth J. Shpall
38 Bone Marrow and Peripheral Blood Cell Donors and Donor Registries, 544
Dennis L. Confer, John P. Miller & Jeffrey W. Chell
39 Cord Blood Hematopoietic Cell Transplantation, 559
Hal E. Broxmeyer & Franklin O. Smith
40 In Utero Transplantation, 577
Alan W. Flake & Esmail D. Zanjani
41 Mobilization of Autologous Peripheral Blood Hematopoietic Cells for Cellular Therapy, 590
Thomas C. Shea & John F. DiPersio
42 Removal of Tumor Cells from the Hematopoietic Graft, 605
John G. Gribben
43 Peripheral Blood Hematopoietic Cells for Allogeneic Transplantation, 618
Norbert Schmitz
44 Cryopreservation of Hematopoietic Cells, 631
Scott D. Rowley
45 Use of Recombinant Growth Factors After Hematopoietic Cell Transplantation, 645
Jürgen Finke & Roland Mertelsmann
46 Hematopoietic Cell Transplantation from Human Leukocyte Antigen Partially Matched Related Donors, 657
Claudio Anasetti, Franco Aversa & Andrea Velardi
47 Hematopoietic Cell Transplantation from Unrelated Donors, 675
Effie W. Petersdorf
48 Donor Selection for Hematopoietic Cell Transplantation, 692
Ann E. Woolfrey
SECTION 5: Hematopoietic Cell Transplantation for Acquired Diseases
49 Hematopoietic Cell Transplantation for Aplastic Anemia, 707
George E. Georges & Rainer Storb
50 Hematopoietic Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria, 727
Robert P. Witherspoon
51 Allogeneic and Autologous Transplantation for Chronic Myeloid Leukemia, 734
Jerald P. Radich & Ravi Bhatia
52 Hematopoietic Cell Transplantation for Juvenile Myelomonocytic Leukemia, 751
Charlotte M. Niemeyer & Franco Locatelli
53 Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia, 761
Frederick R. Appelbaum
54 Hematopoietic Cell Transplantation for Childhood Acute Myeloid Leukemia, 775
Julie-An M. Talano, James T. Casper & David A. Margolis
55 Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Adults, 791
Stephen J. Forman
56 Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Children, 806
Parinda A. Mehta & Stella M. Davies
57 Hematopoietic Cell Transplantation for Myelodysplastic Syndrome and Myeloproliferative Disorders, 827
H. Joachim Deeg
58 Hematopoietic Cell Transplantation for Multiple Myeloma, 845
Muzaffar H. Qazilbash & Sergio A. Giralt
59 Hematopoietic Cell Transplantation for Hodgkin's Disease, 860
Philip J. Bierman & Auayporn Nademanee
60 Non-Hodgkin's Lymphoma, 878
Laura J. Johnston & Sandra J. Horning
61 Hematopoietic Cell Transplantation for Chronic Lymphocytic Leukemia, 897
David B. Miklos
62 Autologous Hematopoietic Cell Transplantation for Systemic Light Chain (AL-) Amyloidosis, 914
Raymond L. Comenzo & Morie A. Gertz
63 Hematopoietic Cell Transplantation for Breast Cancer, 931
Yago Nieto & Elizabeth J. Shpall
64 Hematopoietic Cell Transplantation in Germ Cell Tumors, 948
Christie J. Moore, Brandon Hayes-Lattin & Craig R. Nichols
65 Hematopoietic Cell Transplantation for Renal Cell and other Solid Tumors, 958
Richard W. Childs & Ramaprasad Srinivasan
66 Hematopoietic Cell Transplantation for Neuroblastoma, 970
Jason Law & Katherine K. Matthay
67 Hematopoietic Cell Transplantation for Other Pediatric Solid Tumors, 985
David M. Loeb & Allen R. Chen
68 Hematopoietic Cell Transplantation for Patients with Human Immunodefi ciency Virus Infection, 1001
John A. Zaia, Amrita Krishnan, & John J. Rossi
69 Hematopoietic Cell Transplantation for Autoimmune Diseases, 1014
Richard A. Nash
70 Hematopoietic Cell Transplantation for Rare Hematologic Malignancies, 1030
Vinod Pullarkat & Stephen J. Forman
71 Reduced-intensity Conditioning Followed by Hematopoietic Cell Transplantation for Hematologic Malignancies, 1043
Brenda M. Sandmaier & Rainer Storb
72 Management of Relapse after Hematopoietic Cell Transplantation, 1059
Ginna G. Laport & Robert S. Negrin
SECTION 6: Hematopoietic Cell Transplantation for Inherited Diseases
73 Hematopoietic Cell Transplantation for Thalassemia, 1079
Guido Lucarelli & Javid Gaziev
74 Hematopoietic Cell Transplantation for Sickle Cell Disease, 1090
Mark C. Walters
75 Hematopoietic Cell Transplantation for Immunodefi ciency Diseases, 1105
Trudy N. Small, Wilhelm Friedrich, & Richard J. O'Reilly
76 Hematopoietic Cell Transplantation for Osteopetrosis, 1125
Peter F. Coccia
77 Hematopoietic Cell Transplantation for Storage Diseases, 1136
Charles Peters
78 Hematopoietic Cell Transplantation for Macrophage and Granulocyte Disorders, 1163
Rajni Agarwal
79 Hematopoietic Cell Transplantation for Fanconi's Anemia, 1178
John E. Wagner, Margaret L. MacMillan, & Arleen D. Auerbach
SECTION 7: Complications of Hematopoietic Cell Transplantation
80 Mechanisms and Treatment of Graft Failure, 1203
Robert Lowsky & Hans Messner
81 Blood Group Incompatibilities and Hemolytic Complications of Hematopoietic Cell Transplantation, 1219
Margaret R. O'Donnell
82 Principles of Transfusion Support Before and After Hematopoietic Cell Transplantation, 1226
Jeffrey McCullough
83 Vascular Access and Complications, 1244
I. Benjamin Paz
84 Pharmacologic Prevention of Acute Graft-Versus-Host Disease, 1257
Nelson J. Chao & Keith M. Sullivan
85 T-Cell Depletion to Prevent Graft-versus-Host Disease, 1275
Robert J. Soiffer
86 Manifestations and Treatment of Acute Graft-Versus-Host Disease, 1287
Corey Cutler & Joseph H. Antin
87 Chronic Graft-versus-Host Disease: Clinical Manifestations and Therapy, 1304
Steven Z. Pavletic & Georgia B. Vogelsang
88 Bacterial Infections, 1325
Helen L. Leather & John R. Wingard
89 Fungal Infections after Hematopoietic Cell Transplantation, 1346
Janice (Wes) M.Y. Brown
90 Cytomegalovirus Infection, 1367
John A. Zaia
91 Herpes Simplex Virus Infections, 1382
James I. Ito
92 Varicella-zoster Virus Infections, 1388
Dora Y. Ho & Ann M. Arvin
93 Epstein–Barr Virus Infection, 1410
Wen-son Hsieh & Richard F. Ambinder
94 Adenoviruses, Respiratory Viruses, HHV-6, HHV-7, HHV-8, Papovaviruses and Other Viruses After Hematopoietic Cell Transplantation, 1419
Michael Boeckh
95 Gastrointestinal and Hepatic Complications, 1434
Simone I. Strasser & George B. McDonald
96 Lung Injury Following Hematopoietic Cell Transplantation, 1456
Kenneth R. Cooke & Gregory A. Yanik
97 Kidney and Bladder Complications of Hematopoietic Cell Transplantation, 1473
Sangeeta Hingorani
98 Endocrine Complications Following Hematopoietic Cell Transplantation, 1487
Fouad R. Kandeel
99 Common Potential Drug Interactions Following Hematopoietic Cell Transplantation, 1523
Anne Poon & Lowan Ly
100 Critical Care of the Hematopoietic Cell Transplant Recipient, 1539
Gundeep S. Dhillon & Norman W. Rizk
101 Nutrition Support of the Hematopoietic Cell Transplant Recipient, 1551
Polly Lenssen & Saundra Aker
102 Pain Management, 1570
Noelle V. Frey & Jonathan R. Gavrin
103 Oral Complications of Hematopoietic Cell Transplantation, 1589
Mark M. Schubert & Douglas E. Peterson
104 Growth and Development after Hematopoietic Cell Transplantation, 1608
Jean E. Sanders
105 Delayed Nonmalignant Complications after Hematopoietic Cell Transplantation, 1620
Mary E.D. Flowers & H. Joachim Deeg
106 Secondary Malignancies after Hematopoietic Cell Transplantation, 1638
Smita Bhatia & Ravi Bhatia
107 Neurologic Complications of Hematopoietic Cell Transplantation, 1653
Harry Openshaw
108 Vaccination of Allogeneic and Autologous Hematopoietic Cell Recipients, 1664
Trudy N. Small
SECTION 8: Looking Forward
109 Hematopoietic Cell Transplantation in the Future, 1673
Ernest Beutler
Colorplates, facing page 514
Robert C. Hackman
Index, 1677
