Introduces the fundamental principles and current concepts of toxicology and risk assessment--offering comprehensive discussions on clinical testing, risk assessment of chemicals and hazardous materials, the application of animal data to human health risk assessment, mathematical models, statistical approaches, environmental laws, information resources, and risk management.

Table of Contents:
General Toxicology Principles and Highlights of Toxicology, Arthur Furst and Anna M. Fan Carcinogenesis: Basic Principles, David B. Couch Principles of Genetic Toxicology, Wai Nang Choy Principles Underlying Developmental Toxicity, John M. DeSesso and Stephen B. Harris Principles of Neurotoxicity, I.K. Ho and Anna M. Fan Biology of the Immune System and Immunotoxicity, Kathleen Rodgers Pharmacokinetics and Risk Assessment, Raghubir P. Sharma and Roger A. Coulombe, Jr. Toxicological Testing Acute, Subchronic, and Chronic Toxicity Testing, Ann de Peyster and Moira A. Sullivan Carcinogenicity Testing Methods, J. A. Wisniewski Genetic Toxicology Testing, Wai Nang Choy The Design, Evaluation, and Interpretation of Developmental Toxicity Tests, John M. DeSesso, Stephen B. Harris, and Stella M. Swain Neurotoxicity Testing, I.K. Ho and Anna M. Fan Immunotoxicity Testing, Kathleen Rodgers Basic Elements and Approaches in Risk Assessment Cancer Risk Assessment: Historical Perspectives, Current Issues, and Future Directions, Susan F. Velazquez, Rita Schoeny, Vincent J. Cogliano, and Glenn E. Rice Risk Assessment: Principles and Methodologies, Welford C. Roberts and Charles O. Abernathy Medium-Specific and Multimedium Risk Assessment, Brian K. Davis and A. K. Klein Noncancer Risk Assessment: Present and Emerging Issues, John L. Cicmanec, Michael L. Dourson, and Richard C. Hertzberg Risk Assessment of Chemical Mixtures and Chemical Interactions Predicting the Toxicological Consequences of Multiple Chemical Interactions, Edward H. Calabrese Interaction: An Epidemiological Perspective for Risk Assessment, Kenneth A. Mundt and Carl M. Shy The Median Effect Equation: A Useful Mathematical Model for Assessing Interaction of Carcinogens and Low-Dose Cancer Quantitative Risk Assessment, James Stewart and Edward J. Calabrese Genetic Toxicology and Risk Assessment of Complex Environmental Mixtures, Virginia Stewart Houk and Michael D. Waters The Effect of Combined Exposures of Chlorine, Copper, and Nitrite on Methemoglobin Formation in Red Blood Cells of Dorset Sheep, Cynthia J. Langlois, James A. Garreffi, Linda A. Baldwin, and Edward J. Calabrese Models and Statistical Methods Statistical Methods in Developmental Toxicity Risk Assessment, Yiliang Zhu and Karen Fung Applications of Receptor-Binding Models in Toxicology, J. Denes, D. Blakey, D. Krewski, and J. R. Withey Statistical Analysis of heritable Mutagenesis Data, Walter W. Piegorsch Statistical Analysis of Long-Term Animal Cancer Studies, Gregg E. Dinse Risk Assessment for Nonquantal Toxic Effects, James J. Chen, Ralph L. Kodell, and David W. Gaylor Physiologically Based Pharmacokinetic Modeling of Phenanthrene, I. Chu and Lung-fa Ku Biologically Based Cancer Modeling, E. Georg Luebeck and Suresh H. Moolgavkar Use of Human Data and Animal to Human Data Extrapolation Epidemiology: General Principles, Methodological Issues, and Applications to Environmental Toxicology, Richard G. Ames Use of Epidemiological Data for Assessment of Low Levels of Lead as Neurotoxic and Developmental Toxicants, Jerry J. Zarriello Issues in Data Extrapolation, Joseph P. Brown and Andrew G. Salmon Metam: Animal Toxicology and Human Risk Assessment, Lubow Jowa Effects of Chemical-Chemical Interactions on the Evaluation of Toxicity, Amy L. Yorks and Katherine S. Squibb Risk Assessment: Statutory Requirements and Resource Needs Environmental Laws and Risk Assessment, Denise D. Fort Resource Agencies with Information on Toxic Substances, Health Effects, Hanafi Russell, Todd Miller, and Yi Y. Wang Resources for Toxicology Risk Assessment, Po-Yung Lu and John S. Wassom Electronic Resources for Toxicology and Environmental Health, Mary Ann Mahoney and Charleen Kubota Risk Assessment and Risk Management Role of Risk Assessment in Regulatory Decision Making for Biotechnology: EPA's Experience Under TSCA, Ellie F. Clark Risk Assessment for Risk Management and Regulatory Decision Making at the U.S. Food and Drug Administration, P. Michael Bolger, Clark D. Carrington, and Sara Hale Henry Comparative Risk: Adding Value to Science, Richard A. Minard, Jr. The Use of Comparative Risk Judgments in Risk Management, Carl F. Cranor Risk Assessment in Monitoring, Compliance, and Enforcement, Barton P. Simmons