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Use of Platelet Gel and Fibrin Glue in the Treatment of Periodontal Intrabony Defects: (English)

Use of Platelet Gel and Fibrin Glue in the Treatment of Periodontal Intrabony Defects: (English)

          
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About the Book

This dissertation, "Use of Platelet Gel and Fibrin Glue in the Treatment of Periodontal Intrabony Defects" by Sandeep, Jain, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract Wound healing in periodontal defects following open flap debridement (OFD) is dependent on clot stability between the avascular root surface and the flaps. Recently Platelet Rich Plasma (PRP) has been developed which is produced from a patient's own blood and if applied in a surgical wound stabilizes the clot and releases several growth factors. PRP has been used in periodontal surgery with bone graft materials but there have been no reports on PRP alone in the treatment of periodontal defects. Objective of the present study was to prepare PRP, assess its platelet and growth factor levels, and to evaluate the clinical effects of PRP and PPP gels in access surgery for the treatment of periodontal defects. The participants consisted of 12 subjects with chronic periodontitis who contributed 24 pairs of well-matched defects for this study. Just prior to the surgery, 30 ml of patient's own blood was obtained by venipuncture and separated into PRP gel and platelet poor plasma (PPP) gel by differential centrifugation. The plasma, PRP and PPP were stored at -72 Celsius and their platelet and growth factor levels were analyzed. The mean platelet count was 1144140573020/l which represented an increase of 596% above baseline (pmean value of 168.17 91.45 ng/ml (p(0.471.5mm) but this difference did not reach stastical significance. Nine out of twelve (75%) of the subjects showed greater gain of attachment in the test sites than the control sites at 3 months but this effect was less appreciable at 6 months. This study indicates that PRP of adequate quality for surgical use, containing high levels of platelets and growth factors can be obtained using a general purpose centrifuge. Access flap surgery alone or when combined with application of PRP and PPP is effective in achieving reduction of probing depths and CAL gain in periodontal defects. Adjunctive use of PRP and PPP gels may increase the likelihood of initial greater gain of attachment compared to access surgery alone. DOI: 10.5353/th_b3764521 Subjects: Wound healingBlood plateletsFibrinPeriodontal disease - Treatment


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Product Details
  • ISBN-13: 9781361437469
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 80
  • Spine Width: 4 mm
  • Width: 216 mm
  • ISBN-10: 1361437464
  • Publisher Date: 27 Jan 2017
  • Binding: Paperback
  • Language: English
  • Series Title: English
  • Weight: 209 gr


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Use of Platelet Gel and Fibrin Glue in the Treatment of Periodontal Intrabony Defects: (English)
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