The Third Edition of this classic compendium, Vitamin D, is the most comprehensive, authoritative reference available in the field. In two volumes and over 100 chapters, the editors and authors have marshaled all currently available data on the basic mechanisms, normal physiology and effects on disease of Vitamin D; they have laid out for the reader up-to-date and expert information on the role of vitamin D in health and many disorders. With new chapters on multiple cancers, this complete reference work is essential for anyone working in endocrinology, osteology, bone biology, or cancer research. Volume One chapters cover the chemistry and metabolism of vitamin D, role in mineralization, other target organs, and general physiological effects. Volume Two is more clinically oriented addressing deficiency problems (including diagnosis, interactions in the endocrine system, and involvement in malignancies). Volumes One and Two are now sold separately in print. Volume One ISBN: 9780123870353; Volume Two ISBN: 9780123870346.

Table of Contents:
VOLUME ONE SECTION I: CHEMISTRY, METABOLISM, CIRCULATION 1 Historical Overview of Vitamin D Hector F. Deluca 2 Photobiology of Vitamin D Michael F. Holick 3 The Activating Enzymes of Vitamin D Metabolism (25- and 1a-Hydroxylases) Glenville Jones and David E. Prosser 4 CYP24A1: Structure, Function, and Physiological Role Rene St. Arnaud 5 The Vitamin D Binding Protein: DBP Roger Bouillon 6 Industrial Aspects of Vitamin D Arnold L. Hirsch SECTION II: MECHANISMS OF ACTION 7 VDR J. Wesley Pike 8 Nuclear Vitamin D Receptor: Natural Ligands, Molecular Structure-Function, and Transcriptional Control of Vital Genes Mark R. Haussler, Carol A. Haussler, Jui-Cheng Hsieh, Peter W. Jurutka, and G. Kerr Whitfield 9 Structural Basis for Ligand Activity in VDR Dino Moras and Natacha Rochel 10 Coregulators of VDR-mediated Gene Expression Paul McDonald and Diane R. Dowd 11 Target Genes of Vitamin D: Spatio-temporal Interaction of Chromatin, VDR and Response Elements Carsten Carlberg 12 Epigenetic Modifications in Vitamin D Receptor Mediated Transrepression Shigeaki Kato, Alexander Kouzmenko, Fumiaki Ohtake, and Ryoji Fujiki 13 Vitamin D and Wnt/ß-Catenin Signaling Albert Munoz, José Manuel González-Sancho, and María Jesús Larriba 14 Vitamin D Response Element Binding Protein John S. Adams, Thomas S. Lisse, Hong Chen, Mark S. Nanes, and Martin Hewison 15 Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic Actions Anthony W. Norman and Mathew T. Mizwicki SECTION III: MINERAL AND BONE HOMEOSTASIS 16 Development of the Skeleton Jane B. Lian, Gary S. Stein, Martin Montecino, Janet L. Stein, Andre J. van Wijnen 17 Vitamin D Regulation of Osteoblast Function Renny Franchesci and Yan Li 18 Osteoclasts F. Patrick Ross 19 Molecular Mechanisms for Regulation of Intestinal Calcium and Phosphate Absorption by Vitamin D James Fleet and Ryan D. Schoch 20 The Calbindins: Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6 Sylvia Christakos, Leila Mady, and Puneet Dhawan 21 Mineralization Adele Boskey and Eve Donnelly 22 VITAMIN D Regulation of Type I Collagen Expression in Bone Barbara Kream and Alexander Lichtler 23 Target Genes: Bone Proteins Howard Morris, Paul H. Anderson, Gerald J. Atkins, and David M. Findlay 24 Vitamin D and the Calcium-Sensing Receptor Edward M. Brown 25 Effects of 1,25-Dihydroxyvitamin D3 on Voltage-Sensitive Calcium Channels in Osteoblast Differentiation and Morphology Mary Farach-Carson and William R. Thompson SECTION IV: TARGETS 26 Vitamin D and the Kidney Rajiv Kumar and Peter Tebben 27 Vitamin D and the Parathyroids Justin Silver and Tally Neveh-Many 28 Cartilage Barbara D. Boyan, Maryam Doroudi and Zvi Schwartz 29 Vitamin D and Oral Heath Ariane Berdal, Muriel Molla, Vianney Descroix 30 The Role of Vitamin D and its Receptor in Skin and Hair Follicle Biology Marie B. Demay 31 Vitamin D and the Cardiovascular System David Gardner, Songcang Chen, Denis Glenn, and Wei Ni 32 Vitamin D: A Neurosteroid Affecting Brain Development and Function; Implications for Neurological and Psychiatric Disorders John McGrath, Darryl Eyles, and Thomas Burne 33 Contributions of Genetically Modified Mouse Models to Understanding the Physiology and Pathophysiology of the 25-hydroxyvitamin D-1-alpha Hydroxylase Enzyme [1a(OH)ase] and the Vitamin D Receptor (VDR) David Goltzman, Geoffrey N. Hendy, and Richard Kremer SECTION V: HUMAN PHYSIOLOGY 34 Vitamin D: Role in the Calcium and Phosphorus Economies Robert P. Heaney 35 Fetus, Neonate and Infant Chris Kovacs 36 Vitamin D Deficiency and Calcium Absorption During Childhood Steven A. Abrams 37 Adolescence and Acquisition of Peak Bone Mass Connie Weaver, Rick Lewis, and Emma Liang 38 Vitamin D Metabolism in Pregnancy and Lactation Bonny Specker, Natalie W. Thiex, and Heidi J. Kalkwarf 39 Vitamin D: Relevance in Reproductive Biology and Pathophysiological Implications in Reproductive Dysfunction Hugh S. Taylor and Lubna Pal 40 Vitamin D and the Renin-Angiotensin System Yan Chun Li 41 Parathyroid Hormone, Parathyroid Hormone-Related Protein and Calcitonin John J. Wysolmerski and Elizabeth Holt 42 FGF23/Klotho New Regulators of Vitamin D Metabolism L. Darryl Quarles and Valentin David 43 The Role of the Vitamin D Receptor in Bile Acid Homeostasis David J. Mangelsdorf, Daniel R. Schmidt, Steven A. Kliewer 44 Vitamin D and Fat Clifford J. Rosen and Francisco J. A. de Paula 45 Extra-renal 1a-hydroxylase Martin Hewison and John S. Adams Section VI: Diagnosis and Management 46 Approach to the Patient Michael P. Whyte 47 Detection of Vitamin D and Its Major Metabolites Bruce W. Hollis 48 Bone Histomorphometry Juliet E. Compston and Linda Skingle 49 Radiology Judith E. Adams 50 High-Resolution Imagine Techniques for Bone Quality Assessment Sharmila Majumdar, Andrew J. Burghardt, and Roland Krug 51 The Role of Vitamin D in Orthopaedic Surgery Joseph M. Lane, Aasis Unnanuntana, and Brian J. Rebolledo SECTION VII: NUTRITION, SUNLIGHT, GENETICS, AND VITAMIN D DEFICIENCY 52 Worldwide Vitamin D Status Paul Lips and Natasja van Schoor 53 Sunlight, Vitamin D and Prostate Cancer Epidemiology Gary G. Schwartz 54 Nutrition and lifestyle effects on vitamin D status Susan J. Whiting and Mona S. Calvo 55 Bone Loss, Vitamin D and Bariatric Surgery: Nutrition, Obesity and Bariatric Surgery Lenore Arab and Ian Yip 56 Genes and Risk of Disease André G. Uitterlinden 57 The Pharmacology of Vitamin D Reinhold Vieth 58 How to Define Optimal Vitamin D Status? Roger Bouillon VOLUME TWO SECTION VIII: DISORDERS 59 The Hypocalcemic Disorders: Differential Diagnosis and Therapeutic Use of Vitamin D Thomas O. Carpenter and Karl L. Insogna 60 Vitamin D Deficiency and Nutritional Rickets in Children John M. Pettifor 61 Vitamin D and Osteoporosis Peter R. Ebeling and John A. Eisman 62 Relevance of Vitamin D Deficiency in Adult Fracture and Fall Prevention Heike Bischoff-Ferrari and Bess Dawson-Hughes 63 Clinical Disorders of Phosphate Homeostasis Marc K. Drezner and Karen E. Hansen 64 Pseudo-vitamin D Deficiency Francis H. Glorieux, Thomas Edouard, and René St-Arnaud 65 Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets Peter J. Malloy, David Feldman, and Dov Tiosano 66 Glucocorticoids and Vitamin D Philip Sambrook 67 Drug and Hormone Effects on Vitamin D Metabolism Sol Epstein and Barrie M. Weinstein 68 Vitamin D and Organ Transplantation Elizabeth Shane and Emily M. Stein 69 Vitamin D and Bone Mineral Metabolism in Hepatogastrointestinal Diseases Daniel Bikle 70 Vitamin D and Renal Disease Adriana S. Dusso and Eduardo Slatopolsky 71 Idiopathic Hypercalciuria and Nephrolithiasis Murray J. Favus and Fredric L. Coe 72 Hypercalcemia Due to Vitamin D Toxicity John P. Bilezikian, Natalie E. Cusano, and Susan Thys-Jacobs 73 Vitamin D: Cardiovascular Effects and Vascular Calcification Dwight A. Towler SECTION IX: ANALOGS 74 New Analogs Hector DeLuca and Lori A. Plum 75 Mechanisms for the Selective Actions of Vitamin D Analogs Alex J. Brown 76 Analogs of Calcitriol Annemieke Verstuyf, Pierre De Clercq, Roger Bouillon, Lieve Verlinden, Guy Eelen, and Maurits Vandewalle 77 Analogs and Fx Prevention Noboru Kubodera and Fumiaki Takahashi 78 Non-Secosteroidal Ligands and Modulators Keith R. Stayrook, Yanfei L. Ma, Matthew W. Carson, and Jeffrey A. Dodge 79 The bile acid derivatives lithocholic acid acetate and lithocholic acid propionate are functionally selective vitamin D receptor ligands Makoto Makishima and Sachiko Yamada 80 CYP24A1 Regulation in Health and Disease Martin Petkovich, Tina Epps, and Christian Helvig 81 Calcitriol and Analogs in the Treatment of Chronic Kidney Disease Ravi Thadhani and Ishir Bhan SECTION X: CANCER 82 The Epidemiology of Vitamin D and Cancer Risk Edward Giovannucci 83 Vitamin D: Cancer and Differentiation Johannes P. T. M. van Leeuwen, Alberto Munoz, Marjolein van Driel, and David Feldman 84 Vitamin D Effects on Differentiation and Cell Cycle George P. Studzinski, Elzbieta Gocek, and Michael Danilenko 85 Vitamin D Actions in Mammary Gland and Breast Cancer Joellen Welsh 86 Vitamin D and Prostate Cancer David Feldman and Aruna V. Krishnan 87 The VITAMIN D System and Colorectal Cancer Prevention Heide S. Cross 88 Hematological Malignancy H. Phillip Koeffler and Ryoko Okamoto 89 Vitamin D and Skin Cancer Jean Y. Tang and Ervin H. Epstein 90 The Anti-Tumor Effects of Vitamin D in Other Cancers Donald Trump and Candace Johnson SECTION XI: IMMUNITY, INFLAMMATION, AND DISEASE 91 Vitamin D and Innate Immunity John H. White 92 Control of Adaptive Immunity by Vitamin D Receptor Agonists Luciano Adorini 93 The role of vitamin D in innate immunity: Antimicrobial Activity, Oxidative Stress and Barrier Function Philip T. Liu 94 Vitamin D and Diabetes Chantal Mathieu, Conny Gysemans, and Hannelie Korf 95 Vitamin D and Multiple Sclerosis Colleen E. Hayes, Faye E. Nashold, Justin A. Spanier, Corwin D. Nelson, and Christopher G. Mayne 96 Vitamin D and Inflammatory Bowel Disease Margherita Cantorna and Danny Bruce 97 Psoriasis and other Skin Diseases Jörg Reichrath and Michael F. Holick SECTION XII: THERAPEUTIC APPLICATIONS AND NEW ADVANCES 98 The Role of Vitamin D in Type 2 Diabetes and Hypertension Bess Dawson-Hughes and Anastassios G. Pittas 99 Vitamin D Receptor Agonists in the Treatment of Benign Prostatic Hyperplasia Mario Maggi, Annamaria Morelli, and Luciano Adorini 100 Sunlight protection by Vitamin D Compounds Rebecca S. Mason, Katie M. Dixon, Vanessa Sequiera, and Clare Gordon-Thomas 101 The Role of Vitamin D in Osteoarthritis and Rheumatic Disease Timothy M. McAlindon and M. Kyla Shea 102 Vitamin D and cardiovascular Disease Harald Dobnig and Harald Sourij 103 Vitamin D, Childhood Wheezing, Asthma, and Chronic Obstructive Pulmonary Disease Carlos A. Camargo, Jonathan Mansbach, and Adit Ginde 104 Vitamin D and Skeletal Muscle Function Robert U. Simpson and Lisa Ceglia 105 VITAL JoAnn E. Manson