High Quality Content by WIKIPEDIA articles! Wayne County is the westernmost county located in the U.S. state of West Virginia. As of 2000, the population was 42,903. Its county seat is Wayne. Wayne County is a part of the Huntington-Ashland, WV-KY-OH, Metropolitan Statistical Area (MSA). As of the 2000 census, the MSA had a population of 288,649. According to the U.S. Census Bureau, the county has a total area of 512 square miles (1,327 km), of which, 506 square miles (1,310 km) of it is land and 6 square miles (17 km) of it (1.25%) is water.