Home > Medicine & Health Science textbooks > Pre-clinical medicine: basic sciences > Physiology > Adrenomedullin in the Rat Digestive System: Response to Starvation(English)
Adrenomedullin in the Rat Digestive System: Response to Starvation(English)

Adrenomedullin in the Rat Digestive System: Response to Starvation(English)

          
5
4
3
2
1

Out of Stock


Premium quality
Premium quality
Bookswagon upholds the quality by delivering untarnished books. Quality, services and satisfaction are everything for us!
Easy Return
Easy return
Not satisfied with this product! Keep it in original condition and packaging to avail easy return policy.
Certified product
Certified product
First impression is the last impression! Address the book’s certification page, ISBN, publisher’s name, copyright page and print quality.
Secure Checkout
Secure checkout
Security at its finest! Login, browse, purchase and pay, every step is safe and secured.
Money back guarantee
Money-back guarantee:
It’s all about customers! For any kind of bad experience with the product, get your actual amount back after returning the product.
On time delivery
On-time delivery
At your doorstep on time! Get this book delivered without any delay.
Notify me when this book is in stock
Add to Wishlist
X

About the Book

This dissertation, "Adrenomedullin in the Rat Digestive System: Response to Starvation" by Siu-yin, Man, 文小燕, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled Adrenomedullin in the Rat Digestive System: Response to Starvation Submitted by SIU YIN MAN for the Degree of Master of Philosophy at The University of Hong Kong in August 2005 Starvation has been shown to affect various physiological functions and peptide levels of the gastrointestinal tract. However, the effects of starvation on adrenomedullin (AM) levels in the digestive system have not been studied. Since AM has been shown to be present throughout the digestive system and may be an important regulator of gastrointestinal functions, we hypothesize that starvation may affect the AM system in the digestive system. The present study investigates the effects of acute (1-day) and chronic (4-day) starvation on the levels of immunoreactive-AM (ir-AM), and gene expressions of preproAM and AM receptors in the gastrointestinal system. The effects of acute starvation and AM on glucose uptake in isolated hepatocytes are also investigated. During acute starvation, only the gene expression of preproAM in the fundus of the stomach was up-regulated. After chronic starvation, the concentrations of ir-AM in both the fundus and pylorus were significantly increased. An up-regulation in preproAM gene expression was also detected in the pylorus. These changes might suggest that the secretion of AM might be reduced in the fundus but increased in the pylorus as starvation was prolonged. Moreover, marked reductions in the gene expressions of fundic calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein (RAMP) 3 as well as the pyloric CRLR and RAMP2 were observed in the chronically starved rats. Regarding the pancreas, the ir-AM contents were reduced following chronic starvation, suggesting a possible increase in the inhibitory action of AM on pancreatic insulin release. In the liver, the CRLR mRNA expression was found to be down-regulated. The lack of changes in plasma ir-AM levels in the courses of acute and chronic starvation was strongly suggestive of the paracrine action of AM in the digestive system. In the liver, AM immunoreactivity was detected in the parenchymal and stellate cells lining the sinusoid, suggesting that AM might play a role in the regulation of hepatic metabolism and circulation. In isolated hepatocytes from acutely starved rats, the uptake of glucose, glycerol and alanine was markedly lower than those from the fed rats. A high AM concentration (1000 nM) increased the insulin-stimulated glucose uptake by more than 2-fold whereas lower AM concentrations (10 and 100 nM) reduced the glucagon-induced alanine uptake. The gene expression of RAMP1 was up-regulated by glucose and that of preproAM was increased by glycerol. In similar preparations from fed rats, 1000 nM AM enhanced the basal and insulin-induced glucose uptake. Both glucose and glycerol were found to increase the gene expressions of preproAM and RAMP1. These findings showed that AM might play some roles in the modulation of glucose uptake in hepatocytes. The present study suggests that acute starvation may increase the secretion of AM in the fundus. During chronic starvation, the release of AM may be reduced in the liver and fundus but may be augmented in the pancreas and pylorus. In isolated hepatocytes from acutely starved rats, the uptake of glucose is reduced whereas a high concentration of AM can increase the insulin-induc


Best Sellers


Product Details
  • ISBN-13: 9781361128701
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 184
  • Spine Width: 10 mm
  • Weight: 440 gr
  • ISBN-10: 1361128704
  • Publisher Date: 26 Jan 2017
  • Binding: Paperback
  • Language: English
  • Series Title: English
  • Sub Title: Response to Starvation
  • Width: 216 mm


Similar Products

How would you rate your experience shopping for books on Bookswagon?

Add Photo
Add Photo

Customer Reviews

REVIEWS           
Click Here To Be The First to Review this Product
Adrenomedullin in the Rat Digestive System: Response to Starvation(English)
Open Dissertation Press -
Adrenomedullin in the Rat Digestive System: Response to Starvation(English)
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Adrenomedullin in the Rat Digestive System: Response to Starvation(English)

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book
    Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!
    ASK VIDYA