Home > Medicine & Health Science textbooks > Medical specialties, branches of medicine > Pharmacology > Medical toxicology > Hepatotoxicity – From Genomics to In Vitro and In Vivo Models
4%
Hepatotoxicity – From Genomics to In Vitro and In Vivo Models

Hepatotoxicity – From Genomics to In Vitro and In Vivo Models

          
5
4
3
2
1

Out of Stock


Premium quality
Premium quality
Bookswagon upholds the quality by delivering untarnished books. Quality, services and satisfaction are everything for us!
Easy Return
Easy return
Not satisfied with this product! Keep it in original condition and packaging to avail easy return policy.
Certified product
Certified product
First impression is the last impression! Address the book’s certification page, ISBN, publisher’s name, copyright page and print quality.
Secure Checkout
Secure checkout
Security at its finest! Login, browse, purchase and pay, every step is safe and secured.
Money back guarantee
Money-back guarantee:
It’s all about customers! For any kind of bad experience with the product, get your actual amount back after returning the product.
On time delivery
On-time delivery
At your doorstep on time! Get this book delivered without any delay.
Notify me when this book is in stock
Add to Wishlist
X

About the Book

This book addresses all the current, up-to-date developments in this scientific discipline. Liver is the chief metabolizing site in the body, and thus, it is a major target organ for drug and chemical toxicity. Therefore, hepatotoxicity is an important endpoint in the safety evaluation of drugs and chemicals. Contributions from leading investigators in hepatotoxicity research address current developments in this scientific discipline and discuss use of current cutting edge technology such as microarrays in hepatotoxicity thus providing a better understanding of hepatotoxins, their interactions and mechanisms of action. This valuable authoritative source of information is the first book to address this topic for nearly ten years, making it an essential resource for readers from a wide range of disciplines such as toxicology, pharmacology, hepatology, drug toxicity and food science.

Table of Contents:
Contributors. Preface. Acknowledgements. SECTION 1: MODELS FOR HEPATOTOXICITY TESTING. 1 Current in vitro Models to Study Drug-Induced Liver Injury (Julio C. Davila, Jinghai J. Xu, Keith A. Hoffmaster, Peter J. O'Brien and Stephen C. Storm). 2 Utilization of an in vitro Hepatotoxicity Test in the Early Stage of Drug Discovery (Ikuo Horii, Hiroshi Yamada, Rie Kikkawa, Toshinori Yamamoto, Tamio Fukushima and Kaori Tomizawa). 3 Use of Hepatocytes for Characterizing a Candidate Drug's Metabolism and Drug Interaction Potential (Srikanth C. Nallani, John M. Strong and Shiew Mei Huang). 4 Human-Based in vitro Experimental Systems for the Evaluation of Human Drug Safety (Albert P. Li). 5 Hepatocytes as a Model for Screening Food-Related Hepatotoxins and Studying Mechanisms of their Toxicity (Saura C. Sahu). 6 Some Experimental Models of Liver Damage (Pablo Muriel). SECTION 2: HEPATOCYTE CULTURES. 7 Application of Short- and Long-Term Hepatocyte Cultures to Predict Toxicities (Gregor Tuschl, Jens Hrach, Philip G. Hewitt and Stefan O. Mueller). SECTION 3: BIOMARKERS OF HEPATOTOXICITY. 8 Biomarkers of Mycotoxin Exposure in Liver Toxicity (Angela J. Harris). SECTION 4: MECHANISMS OF HEPATOTOXICITY. 9 Mechanisms of Toxic Liver Injury (Nora Anderson and J..urgen Borlak). 10 A Role of Cytochrome P450 in Quinone-Induced Hepatotoxicity (Yasuhiro Ishihara and Norio Shimamoto). 11 A Mechanistic View of Troglitazone Hepatotoxicity (Rawiwan Maniratanachote and Tsuyoshi Yokoi). 12 Role of the Kupffer Cell in Hepatotoxicity and Hepatocarcinogenesis (James E. Klaunig, Stacy M. Corthals, Lisa M. Kamendulis and Binu K. Philip). 13 Sinusoidal Cells in Liver Injury and Repair (Carol R. Gardner and Debra L. Laskin). 14 Cytokines in Liver Diseases (Pablo Muriel). 15 Bile Acids as Modulators of Apoptosis (Rui E. Castro, Susana Sol'a, Clifford J. Steer and Cec'ilia M.P. Rodrigues). 16 Drug-Induced Intrahepatic Cholestasis by Interaction with the Hepatic Bile Salt Export Pump (BSEP) (Christoph Funk, Johannes No'e, Ren'ee Portmann, Ruben Alvarez-S'anchez, Florian Klammers, Christiane Lamy, Axel Paehler and Michael Pantze). SECTION 5: GENOMICS OF HEPATOTOXICITY. 17 Application of Toxicogenomics in Predicting Hepatotoxicity - Potentials and Challenges (Wen Lin, Guoxiang Shen, Tin Oo Khor and Ah-Ng Tony Kong). 18 Genomic Profiling of Liver Injury (Kevin Gerrish and David E. Malarkey). 19 Use of DNA Arrays in Understanding Hepatic Test Systems (Angela J. Harris and Daniel A. Casciano). 20 Prediction of Hepatotoxicity Based on the Toxicogenomics Database (Tetsuro Urushidani). 21 Relationship between N-acetyltransferase-2 Gene Polymorphism and Isoniazid-Induced Hepatotoxicity (Yasuo Shimizu, Kunio Dobashi and Masatomo Mori). SECTION 6: GENDER DIFFERENCES IN HEPATOTOXICITY. 22 Human and Animal-Based Differences in Hepatic Xenobiotic Metabolism and Toxicity (Peter J. O'Brien, Katie Chan and Raymond J. Poon). SECTION 7: HEPATOTOXICITY AND HEPATOCARCINOGENICITY. 23 Hepatotoxicity in Oncology Drug Development (Wei Chen, Kenneth Hastings and John K. Leighton). 24 The Potent Rat Hepatocarcinogen Methapyrilene: An Hypothesis Regarding its Hepatotoxicology (Daniel A. Casciano). SECTION 8: HEPATOTOXICITY AND BOTANICAL SUPPLEMENTS. 25 Botanical Supplements and Hepatotoxicity (Shabana Khan, Ikhlas Khan and Larry Walker). SECTION 9: RISK ANALYSIS OF HEPATOTOXINS. 26 Physiologically Based Pharmokinetic Modeling and Risk Assessment of Hepatotoxicants (Kannan Krishnan). Index.


Best Sellers


Product Details
  • ISBN-13: 9780470516751
  • Publisher: John Wiley and Sons Ltd
  • Publisher Imprint: Wiley-Blackwell
  • Height: 249 mm
  • No of Pages: 704
  • Spine Width: 44 mm
  • Width: 179 mm
  • ISBN-10: 0470516755
  • Publisher Date: 27 Feb 2008
  • Binding: Other digital
  • Language: English
  • Returnable: Y
  • Weight: 1344 gr


Similar Products

How would you rate your experience shopping for books on Bookswagon?

Add Photo
Add Photo

Customer Reviews

REVIEWS           
Click Here To Be The First to Review this Product
Hepatotoxicity – From Genomics to In Vitro and In Vivo Models
John Wiley and Sons Ltd -
Hepatotoxicity – From Genomics to In Vitro and In Vivo Models
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Hepatotoxicity – From Genomics to In Vitro and In Vivo Models

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book
    Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!
    ASK VIDYA