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Insulin-Like Growth Factor I and Linear Growth at Birth to Five Days in Rats: (English)

Insulin-Like Growth Factor I and Linear Growth at Birth to Five Days in Rats: (English)

          
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About the Book

This dissertation, "Insulin-like Growth Factor I and Linear Growth at Birth to Five Days in Rats" by Yue-sin, Chan, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of dissertation entitled Insulin-like Growth Factor I and Linear Growth at Birth to Five Days in Rats Submitted by Flora Yue Sin CHAN for the degree of Master of Medical Science at the University of Hong Kong, HKSAR, China December 2001 Insulin-like growth factor I (IGF-I) and II are essential growth factors for growth at cellular level during intrauterine development of an embryo and a fetus, while both IGF-I and growth hormone (GH) play profound roles in postnatal growth, development and metabolic homeostasis. Human studies have shown that an abrupt increase in body length velocity in early life, i.e. 6 to 15 months of age, is accompanied by a significant increase in serum IGF-I and length velocity, representing the age at which GH starts to regulate linear growth significantly. But in rodents, i.e. rats, the onset age of GH action on postnatal linear growth is still unknown. The aim of this study was to identify the onset of the GH dependent phase of linear growth in normal rats. It has been hypothesized that fetal growth is regulated virtually independent of GH. In rats, the GH dependent linear growth phase should, according to available information, start its onset during the first five days of life. Eighty experimental and ten control newborn rats were included in the study and followed from birth to five days of life. A Homologous Rat IGF-I EnzymeImmunoassay (EIA) kit was applied to measure serum IGF-I level. Growth parameters i.e. body weight (g), body + tail length (cm), tail length (cm) and body length (cm) were measured by repeated measurement method. Our EIA results revealed that the mean serum IGF-I level increased between day 0.5 and day 4.5 from 89.3 (62.2 SD) ng/ml to 222.6 (113.7 SD) ng/ml, i.e. a 2.5-fdld increase. Un-paired t-test results also showed there was a significant increase in the total circulation form of serum IGF-I level between day 2.5 and day 3.5, i.e. from 109.8 ng/ml to 201.3 ng/ml (p DOI: 10.5353/th_b3040915 Subjects: Insulin-like growth factor-binding proteinsRats - GeneticsRats - Growth


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Product Details
  • ISBN-13: 9781361407851
  • Publisher: Open Dissertation Press
  • Publisher Imprint: Open Dissertation Press
  • Height: 279 mm
  • No of Pages: 76
  • Spine Width: 6 mm
  • Width: 216 mm
  • ISBN-10: 1361407859
  • Publisher Date: 27 Jan 2017
  • Binding: Hardback
  • Language: English
  • Series Title: English
  • Weight: 472 gr


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