Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.

Table of Contents:
Principles of Toxicology Harming and Helping Through Time: The History of Toxicology, R.W. Lane and J.F. Borzelleca The Use of Toxicology in the Regulatory Process, B.D. Beck, E.J. Calabrese, T.M. Slayton, and R. Rudel Metabolism: A Determinant of Toxicity, R. Kemper, J.R. Hayes, and M.S. Bogdanffy Toxicokinetics, A.G. Renwick Physiologically Based Pharmacokinetic and Toxicokinetic Models, K.Krishnan and M.E. Andersen Toxicopanomics: Applications of Genomics, Proteomics, and Metabonomics in Predictive and Mechanistic Toxicology, D. Robertson, S. Beushausen, and W. Pennie The Toxicologic Assessment of Pharmaceutical and Biotechnology Products, M.A. Dorato, C. McMillian, and M.J. Vodicnik Statistics for Toxicologists, S. C. Gad Quantitative Extrapolations in Toxicology, J.V. Rodricks, D.M. Gaylor, and D. Turnbull The Practice of Exposure Assessment, D.J. Paustenbach and A.K. Madl Epidemiology for Toxicologists, R.R. Cook Principles of Pathology for Toxicology Studies, S.R. Frame and P.C. Mann The Information Infrastructure of Toxicology, P. Wexler, P. Hakkinen, P. Nance, A. Parker, and J. Patterson Agents Foodborne Toxicants, C.S. Reddy and A. Wallace Hayes Solvents and Industrial Hygiene, D.L. Dahlstrom and M. Buckalew Crop Protection Chemicals: Mechanism of Action and Hazard Profiles, C.B. Breckenridge and J.T. Stevens Metals, J.C. Merrill, J.J.P. Morton, and S.D. Soileau Ionizing Radiation, L.G. Cockerham, T.L. Walden, Jr., C.E. Dallas, G.A. Mickley, Jr., and M.A. Landauer Plant and Animal Toxins, F.W. Oehme and D.E. Keyler Methods The Use of Laboratory Animals in Toxicology Research, W.J. White, C.T. Hawk, and M.A. Vasbinder Validation and Regulatory Acceptance of New, Revised, and Alternative Toxicological Methods, W.S. Stokes and L.M. Schechtman Acute Toxicity and Eye Irritancy, M.E. Blazka and A. Wallace Hayes Genetic Toxicology, D.J. Brusick, W.R. Fields, B.C. Myhr, and D.J. Doolittle Short-Term, Subchronic, and Chronic Toxicology Studies, N.H. Wilson, J.F. Hardisty, and J.R. Hayes Principles of Testing for Carcinogenic Activity, G.M. Williams, M.J. Iatropoulos, and H.G. Enzmann Principles of Clinical Pathology for Toxicology Studies, R.L. Hall and N.E. Everds Dermatotoxicology, B.B. Hayes, E. Patrick, and H. Maibach Inhalation Toxicology, R. Valentine and G.L. Kennedy Detection and Evaluation of Chemically Induced Liver Injury, G.L. Plaa and M.Charbonneau Principles and Methods for Renal Toxicology, L.H. Lash Gastrointestinal Toxicology, R.W. Kapp, Jr. Principles and Methods of Cardiac Toxicology, Y.J. Kang Assessment of Male Reproductive Toxicity, S.D. Perreault, G.R. Klinefelter, and E. Clegg Test Methods for Assessing Female Reproductive and Developmental Toxicology, M.S. Christian Hormone Assays and Endocrine Function, R.W. Kapp, Jr., and J.A. Thomas Immunotoxicology: Effects of and Response to Drugs and Chemicals, J.H. Dean, R.V. House, and M.I. Luster Assessment of Behavioral Toxicity, D.A. Cory-Slechta and B. Weiss Application of Isolated Organ Perfusion Techniques in Toxicology, H.M. Mehendale Organelles as Tools in Toxicology, B.A. Fowler, M.L. Haasch, K.S. Squibb, and A. Wallace Hayes Analysis and Characterization of Enzymes and Nucleic Acids, F.P. Guengerich and C.J. Bartleson Modern Instrumental Methods for Studying Mechanisms of Toxicology, P.A. Crooks, D.R. Worthen, G.D. Byrd, J.D. deBethizy, and W.S. Caldwell Methods in Environmental Toxicology, M.A. Lewis, A. Fairbrother, and R.E. Menzer Glossary Index